Relieve Stress, Comfort Pets

Enzyme-Treated Asparagus Extract in short. ETAS is a proprietary ingredient made in Japan, for human and animals made from the tough portion (stem) of asparagus, which is an up-cycled agricultural product. It is manufactured in an innovative way that ETAS has unique chemical profiles different from the regular asparagus extract. After much research was done to filter through many vegetables and other plants, the innovator of ETAS found that asparagus was the most potent candidate for the unique mechanism of action to release stress and other health benefits while it still has to go through the special manufacturing process. ETAS is the only nutraceutical ingredient known to induce heat shock proteins. ETAS has been clinically tested in human and some animals (*rodents to be exact, not tested on dogs or cats besides anecdotal data) to induce heat shock proteins, especially HSP70.

Heat shock proteins (HSPs) are a group of proteins that play a critical role in helping cells manage stress. They're often referred to as "molecular chaperones" because they assist in the proper folding of other proteins and help prevent misfolding and aggregation, which can lean lead to cellular damage. As the name "heat shock" represents, it particularly responds to the stress from heat, but it does not limit to that: in fact the response is also triggered by other types of stress such as oxidative stress, exposure to toxins, and infections. Heat shock proteins also help protect cells that are exposed to stressful conditions in several ways: refolding of damaged proteins into correct form, preventing such misfiled proteins (due to stress) from accumulatin in the body by repairing and removign if the cells cannot be repaired, and facilitating degradation and recycling damaged proteins.

There are several types of heat shock proteins classified by their molecular weight and HSP70 has been the most researched type, involved in folding and protection of proteins. Various diseases are considered to be lined to dysfunctions of heat shock proteins such as cancers, neurodegenerative disorders and cardiovascular diseases. Therefore, heat shock proteins are considered to eb crucial for cellular health and stress management.

In dogs, these proteins help protect cells from damage caused by extreme temperatures, toxins, and other stressors. The above-mentioned functions of heat shock proteins works similar in dogs when they are exposed to various stress factors including heat stress, which is a common issue in dogs causing many to suffer from heat stroke, which can lead to death. It can also influence immunity by modulating inflammation. Also preventing excessive inflammation can help mitigate tissue and organ damages. Aside from the heat stroke, some chronic diseases may be mitigated by heat shock proteins such as cancers, neurodegenerative diseases, and cardiovascular diseases.

Some breeds are more prone to heat stress due to their anatomy and may benefit more from heat shock proteins to cope with heat. Other dogs in today's world can also get stress from genetic and environmental factors. Dogs exposed to chronic environmental stressors and poor living conditions may undergo dysregulation of heat shock proteins and this could impact their overall health and quality of life.

More research is being conducted and examining the benefit of heat shock proteins and applications to the overall canine health and stress-related conditions.