Why Chewtraceuticals®?

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Enzyme-Treated Asparagus Extract in short. ETAS® is a proprietary ingredient made in Japan, for human and animals made from the tough portion (stem) of asparagus, which is an up-cycled agricultural product. It is manufactured in an innovative way that ETAS® has unique chemical profiles different from the regular asparagus extract. After much research was done to filter through many vegetables and other plants, the innovator of ETAS® found that asparagus was the most potent candidate for the unique mechanism of action to release stress and other health benefits while it still has to go through the special manufacturing process. ETAS® is the only nutraceutical ingredient known to induce heat shock proteins. ETAS® has been clinically tested in human and some animals (*rodents to be exact, not tested on dogs or cats besides anecdotal data) to induce heat shock proteins, especially HSP70.

Heat shock proteins (HSPs) are a group of proteins that play a critical role in helping cells manage stress. They're often referred to as "molecular chaperones" because they assist in the proper folding of other proteins and help prevent misfolding and aggregation, which can lean lead to cellular damage. As the name "heat shock" represents, it particularly responds to the stress from heat, but it does not limit to that: in fact the response is also triggered by other types of stress such as oxidative stress, exposure to toxins, and infections. Heat shock proteins also help protect cells that are exposed to stressful conditions in several ways: refolding of damaged proteins into correct form, preventing such misfiled proteins (due to stress) from accumulatin in the body by repairing and removign if the cells cannot be repaired, and facilitating degradation and recycling damaged proteins.

There are several types of heat shock proteins classified by their molecular weight and HSP70 has been the most researched type, involved in folding and protection of proteins. Various diseases are considered to be lined to dysfunctions of heat shock proteins such as cancers, neurodegenerative disorders and cardiovascular diseases. Therefore, heat shock proteins are considered to eb crucial for cellular health and stress management.

In dogs, these proteins help protect cells from damage caused by extreme temperatures, toxins, and other stressors. The above-mentioned functions of heat shock proteins works similar in dogs when they are exposed to various stress factors including heat stress, which is a common issue in dogs causing many to suffer from heat stroke, which can lead to death. It can also influence immunity by modulating inflammation. Also preventing excessive inflammation can help mitigate tissue and organ damages. Aside from the heat stroke, some chronic diseases may be mitigated by heat shock proteins such as cancers, neurodegenerative diseases, and cardiovascular diseases.

Some breeds are more prone to heat stress due to their anatomy and may benefit more from heat shock proteins to cope with heat. Other dogs in today's world can also get stress from genetic and environmental factors. Dogs exposed to chronic environmental stressors and poor living conditions may undergo dysregulation of heat shock proteins and this could impact their overall health and quality of life.

More research is being conducted and examining the benefit of heat shock proteins and applications to the overall canine health and stress-related conditions.

L-Methylfolate is the bioactive form of folate that supports healthy brain function, nervous system activity, and overall wellness in pets. Unlike standard folic acid, L-Methylfolate is already in its usable form, allowing your pet’s body to absorb and utilize it efficiently. This is especially important for pets that may have difficulty converting folic acid due to genetics, age, or stress. By supporting key metabolic processes and healthy red blood cell production, L-Methylfolate contributes to sustained energy levels and optimal cellular function in dogs.

In addition to physical health, L-Methylfolate plays a crucial role in neurotransmitter production that supports mood balance, cognitive health, and emotional well-being in pets. These neurotransmitters are involved in regulating calm behavior, focus, and stress response, making L-Methylfolate a valuable nutrient for pets experiencing anxiety, environmental stress, or age-related cognitive changes. When included as part of a comprehensive pet supplement, L-Methylfolate helps promote mental clarity, balanced mood, and long-term brain health for a happier, healthier pet.

 Vitamin B12 is an essential nutrient that supports healthy energy production, nervous system function, and overall vitality in pets. It plays a key role in converting food into usable energy, helping dogs and cats maintain stamina, strength, and daily activity levels. Vitamin B12 also supports red blood cell formation and healthy metabolism, making it especially important for pets with digestive sensitivities, aging pets, or those experiencing low energy or nutrient absorption challenges. Because Vitamin B12 is water-soluble, it is safely utilized by the body and supports consistent cellular function.

In addition to physical energy, Vitamin B12 is vital for brain health and balanced mood in pets. It supports proper nerve signaling and neurotransmitter function, which can influence behavior, mental clarity, and emotional stability. Adequate Vitamin B12 levels may help support focus, calm behavior, and cognitive function, particularly in pets exposed to stress or age-related neurological changes. When included in a high-quality pet supplement, Vitamin B12 helps promote sustained energy, healthy mood, and long-term nervous system health for a more active and content pet.

Lion’s Mane Mushroom is a functional mushroom known for its ability to support brain health, cognitive function, and nervous system wellness in pets. Rich in naturally occurring compounds that support nerve growth and neural communication, Lion’s Mane helps promote mental clarity, focus, and healthy brain aging in dogs and cats. This makes it especially beneficial for senior pets, pets experiencing age-related cognitive decline, or those needing extra neurological support. By nourishing the nervous system at a cellular level, Lion’s Mane Mushroom supports long-term cognitive health and overall vitality.

In addition to cognitive support, Lion’s Mane Mushroom may help promote calm behavior and emotional balance by supporting healthy brain signaling and stress response. Pets exposed to environmental stress, changes in routine, or anxiety may benefit from Lion’s Mane’s ability to support balanced mood and mental resilience. When included in a high-quality pet supplement, Lion’s Mane Mushroom helps support focus, memory, and emotional well-being—contributing to a happier, more engaged, and mentally sharp pet at any stage of life.